Apolipoprotein E e4 Allele is Associated With More Rapid Motor Decline in Older Persons
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چکیده
منابع مشابه
The Apolipoprotein E e4 Allele and Outcome in Cerebrovascular Disease
Background and Purpose—Polymorphism of the apolipoprotein E gene (APOE) may influence outcome after traumatic brain injury and intracerebral hemorrhage, with the e4 allele being associated with poorer prognosis. We investigated APOE allele distribution in acute stroke and the effect of the e4 allele on outcome. Methods—APOE genotypes were determined in 714 stroke patients: 640 ischemic stroke a...
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BACKGROUND The neurobiological changes underlying the association of the apolipoprotein E (APOE) e4 allele with level of cognition are poorly understood. OBJECTIVE To test the hypothesis that amyloid load can account for (mediate) the association of the APOE e4 allele with level of cognition assessed proximate to death. METHODS There were 44 subjects with clinically diagnosed Alzheimer's di...
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Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment...
متن کاملThe apolipoprotein E e2 allele and decline in episodic memory
Objectives: The apolipoprotein E (apoE) e4 allele is related to decline in multiple cognitive domains, especially episodic memory, but the effect of the e2 allele on change in different forms of cognitive function has been difficult to establish. Methods: Participants are from the Religious Orders Study. At baseline, they were at least 65 years old and free of clinical evidence of dementia. For...
متن کاملApolipoprotein E4 is associated with primary localized cutaneous amyloidosis.
Apolipoprotein E (apoE) is a lipid transport protein, which is a component of lipoproteins, such as very low density lipoprotein, intermediate density lipoprotein, high density lipoprotein, and chylomicron. ApoE is also produced and secreted in the skin, and is implicated to play roles in epidermal differentiation and proliferation (Barra et al, 1994). We have reported that apoE was a component...
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ژورنال
عنوان ژورنال: Alzheimer Disease & Associated Disorders
سال: 2009
ISSN: 0893-0341
DOI: 10.1097/wad.0b013e31818877b5